In depression, monoamine oxidase inhibitor increases .it, resulting in decreased release of neurotransmitters such as dopamine, serotonin and epinephrine. The chemical changes in the brain may cause negative thoughts, vibes, hopefulness, and even think about attempting suicide. These are the primary symptoms of depression. At this time, Words of encouragement to a friend who is feeling down are mandatory to save the life of a beloved. Restore their mental health and bring them back to the glitters of life.